Certainly. You can only ever have one active relationship between a Fact and a given Dimension table, this means possible other relationships between the two will always be inactive. Filters however will only flow through the active relationship to the fact table.
In some cases that is not desirable and two fields should be considered equal. You can either choose to have no relationships OR only inactive relationships between the Fact and that given Dimension table. When there is ‘no relationship’ you can create one on the fly using TREATAS for example but in the case of an ‘inactive relationship’ you can ‘activate’ it using USERELATIONSHIP inside your calculation.
A common example is ‘events in progress’ here’s a link to a post by @Greg on that topic.
I hope this is helpful